COPTIGATE - THE SUMMARY PLUS EDITION!

Updated highlights from my writing on the topic of codon optimization for those who have never heard about it before (or for those who wish to share it with others).

2024 AUTHOR COMMENTS

This article is a capture of my 4th thread on Twitter/X on the topic, which was published on SEPTEMBER 2021. It’s was an attempt to capture in bullet points the main points from the lengthy 3 posts that came before it. This simplified edition is very useful for people who are new to the topic and want to understand what I exposed. I’ve added two important crucial element which was missing in my original thread:

1. The role of protein aggregation and aggresomes failures in misfolded protein related diseases

2. The relationship between prion proteins and cancer.

The 101

Before you bombard experts with endless requests to comment on the validity of what I write, please read this thread, then go to the previous threads (links below), and see the references I use. There is MUCH MORE INFORMATION in my previous threads!

1. Inconsequential (“silent”) mutations are known as synonymous mutation.

2. Synonymous mutations contribute to cellular processes which are determining protein structure and function.

3. Synonymous mutations influence protein folding.

4. Protein misfolding leads to an aggregation of the protein meaning they start to clump together. These protein aggregates can interfere with cellular functions, disrupt normal cellular processes, and lead to toxicity.

5. The cell tries to handle it by aggregated misfolded proteins by creating cellular structures which are formed in response to the accumulation of misfolded protein, called aggresomes.

6. The aggregated misfolded proteins are being transported along microtubules by motor proteins, where the cell starts a autophagy process, which is a cellular process in which damaged or unnecessary cellular components are being degraded.

7. The mitochondria play a crucial role in the aggresomes process, providing energy, Reactive Oxygen Species (ROS) generation, and the regulation of autophagy.

8. Since the SARS_COV_2 spike (which is what all the “vaccines” manufacture) also targets the mitochondria and causes mitochondria failures, the ability of cells with aggregated misfolded proteins to dismantle them is being greatly diminished.

9. Protein misfolding has been linked with neurodegeneration in Alzheimer and Parkinson disease, and many other pathologies.

10. Protein misfolding resulting in intracellular PAO accumulation is sufficient to cause cardiomyocyte death and heart failure. (image taken from this article on the subject).
    

    

11. In recent years it was found that prion proteins are involved in various aspects of cancer biology.

12. For example, these misfolded proteins, known as prions, cause a number of rare brain disorders, such as kuru, bovine spongiform encephalopathy (“mad cow” disease), and Creutzfeldt-Jakob disease.

13. The last decade has seen an exponential increase in published research on the topic of synonymous mutations.

14. Most studies that linked synonymous mutations to diseases focused on a single (or very few) nucleotide* substitutions. (*nucleotide - genetic letter.)

15. Codon optimization creates a large-scale alteration of the gene sequence.

16. Up until recently, codon optimization technology was only used for research and in the manufacturing of therapeutic proteins.

17. SARS_CoV_2, as well as all its variants/mutations are called wild type (WT), which describes their original form (in nature).

18. Pfizer, Moderna, AstraZeneca, Janssen etc. all use codon optimization, on top of other elements; their products do not generate WT.

19. There is a lack of understanding on the difference between proteins synthesized using codon optimization compared to those which did not pass a codon optimization process.

20. Using the codon optimization technology gives multiple advantages to the manufacturers.

21. HOWEVER, Codon optimized proteins carry potential risks as their modified nucleotide sequences may have unpredictable effects on the structure and function of proteins.

22. For example, codon optimization can achieve efficiency in creating large amounts of the required protein (eg spike), but doing so at the expense of the accuracy of the protein being manufactured, resulting in generating unknown proteins due to errors/misreading.

23. Another example: codon optimization might change the shape of the protein, which in result will lead the immune system to be trained to detect a wrong pathogen thus greatly reducing its ability to stop the pathogen, in our case SARS_CoV_2 and its mutants.

24. It is therefore necessary to have well qualified methods that are fit-for-purpose and can be used to evaluate the risk of codon optimization during drug development and manufacture. The regulators did not have such framework in place.

25. Prior to COVID19, the use of gene therapy was extremely limited, so even though regulatory agencies were well aware of the need for methods and processes, the limited use and the long review process deemed sufficient to identify codon optimization side effects.

26. Because in 2020 the WHO has declared COVID19 as a pandemic, and since governments across the world followed happily by implementing emergency regulations, the medical regulators had been instructed to get vaccines approved as fast as possible.

27. All the gene therapies which were introduced as vaccines to the SARS_CoV_2 virus and it's variants went via a fast-track process such as the FDA's Emergency Use Authorization (EUA).

28. The use of the fast-track approval process created a gap where the assumption that codon optimization side effects will be able to be identified as part of the review process, as there was no regulatory process to review risks related to codon optimization.

29. HOWEVER, since the fast-track process has been chosen, the risks which were usually being measured as part of the normal process were not measured.
    24) The codon optimization related risks are not even required to be measured in the FDA's BLA for Pfizer vaccine.

30. The fact manufacturers use a technology which they are fully aware of is problematic, and the fact regulators are fully aware of it but do not even have a process to review it, tells you everything you need to know about the validation process and it's value.

31. Not measuring a risk does not make it go away, just makes it become invisible.

32. The only one who takes the risk is YOU, because all the countries in the world have signed a full indemnity to manufacturers and anyone who administers their products (see my #PfizerLeak articles here).

33. The purpose of the #COptiGate threads was to help people realize the risks related to codon optimization, which no one seems to have bothered to tell them that they exist.

34. The silence of the scientific community and media on the matter is a huge disgrace.

35. One's education does not make them a scientist. One's position of power (government or academia) does not make them trustworthy. PLEASE, STOP TRUSTING "AUTHORITIES". It is YOUR health, it is YOUR safety, it is YOUR life. YOU HAVE THE RIGHT TO QUESTION EVERYTHING!

36. My previous articles on the topic:
    
    COPTIGATE - THE WORST DESIGN FLAW IN HUMAN HISTORY THAT IS IMPACTING YOUR HEALTH and COPTIGATE - 3D CHESS EDITION Can be found here.
    

    “REVERSE ENGINEERING: WHAT DO WE KNOW ABOUT THE GENETIC CODE WITHIN THE PFIZER VACCINE?” Can be found here.

See you in the next article, the “#COptiGate, 2022 Xmas Edition.”, which is today one of the most censored article on X/Twitter!

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Ehden